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Treatment of NSCLC Pharmaceutical Raw Material Oncology Drug APIs Erlotinib Hydrochloride for research for Anti Cancer

Treatment of NSCLC Pharmaceutical Raw Material Oncology Drug APIs Erlotinib Hydrochloride for research for Anti Cancer

Categories Oncology Drug APIs
Model Number: Oncology Drug APIs
Certification: SGS
Place of Origin: Hubei, China
MOQ: 100g
Price: $1.0/grams
Payment Terms: We accept T/T, L/C, Western Unoin, Money Gram, and Bitcoin as payment only.
Supply Ability: 10000Kg/month
Delivery Time: 5-12 days
Packaging Details: Aluminum Foil Bags or Fiber Drum.
Powder: Yes
Purity: 99.6%
Grade: Pharmaceutical grade
Customerized: Customerized
Market: Mainland China Hong Kong,Macao and Taiwan North America South America Western Europe Eastern Europe Eastern Asia Southeast Asia Mid East Africa Oceania Worldwide.
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    Treatment of NSCLC Pharmaceutical Raw Material Oncology Drug APIs Erlotinib Hydrochloride for research for Anti Cancer

    Chemical Information

    Product NameErlotinib hydrochloride
    Molecular FormulaC22H24ClN3O4
    Molecular Weight429.91
    StorageStore at -20°C
    TargetsHER1 EGFR
    IC502 nM 2 nM

    Erlotinib hydrochloride

    CAS 183319-69-9

    CAS 183319-69-9Brand: NEWBIO
    MW 429.9MOQ: 100grams
    Product Categories:API;Molecular Targeted Antineoplastic;Heterocyclic Compounds;anti-neoplastic;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
    UsageErlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. It is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR). It is marketed in the United States by Genentech and OSI Pharmaceuticals and elsewhere by Roche.
    ApplicationsErlotinib hydrochloride , Pharmaceutical raw materials

    Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM in cell-free assays, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.
    Erlotinib HCl (1 μM) induces apoptosis in DiFi humancolon cancer cells. Erlotinib inhibits growth of a panel of NSCLC cell lines including A549, H322, H3255, H358 H661, H1650, H1975, H1299, H596 with IC50 ranging from 29 nM to >20 μM. Erlotinib HCl(2 μM) significantly inhibits growth of AsPC-1 and BxPC-3 pancreatic cells.

    Cells were treated with single dose of erlotinib (1 µM, 24 hours), The greatest cell death was observed in the Txt->OSI-774->media sequence, while the cells treated with the OSI-774->Txt->media sequence resumed proliferation by 72hrs post-treatment. Cleaved PARP and Caspase-3 were detected in the sequence of Txt->OSI-774, and with simultaneous treatment, but not in the sequence of OSI-774->Txt. Further, cleaved PARP and Caspase-3 persisted to 72hrs after the Txt->OSI-774 treatment. These data support the previous results on sub-G1 cells, and molecularly demonstrate an apoptotic response.
    Erlotinib had significant dose-dependent efficacy. In the 100mg/kg group there was growth inhibition of 61%. The other groups had the following growth inhibition: 25mg/kg: 46%; 12.5mg/kg: 36%; 6.25mg/kg: 28%. There were no partial or complete regressions.


    Wuhan Newbio Pharm-tech Co., Ltd.
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    #1 Products can be sent out within 24 hours after payment.
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    #1 We are manufacturer with own factory and we sale this product at a best quality and low price.
    #2 All product listed is available in stock, please contact the sale for more details.
    #3 We have QA&QC department to guarantees the quality, product pass rate can reach 100%.
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    #1 Pharmaceutical raw material,
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